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Quick Answer: Muscle pain is not a recognized common side effect of GLP-1 receptor agonists based on FDA prescribing information and clinical trial data, though some patients report muscle discomfort likely related to rapid weight loss and muscle mass reduction rather than direct drug toxicity

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Unpleasant Side Effects The side effects of GLP-1 RAs are primarily gastrointestinal, and often include nausea, vomiting, diarrhea, bloating, and belching

Additionally, "GLP-1 medications work differently because they are engineered to stay active much longer, which is why they have a much more powerful and sustained effect on appetite and blood sugar regulation," he said

These developments represent a sea change for Medicare GLP-1 access and will significantly increase the volume of ePA transactions as millions of previously excluded beneficiaries gain coverage