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CAS 77591-33-4), a naturally occurring 43-amino acid polypeptide found in virtually all mammalian cells
The rats were maintained in an animal room with an air-conditioned barrier system at an ambient temperature of 25C 2C, relative humidity of 50% 10%, and a 12 h light/dark cycle
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NO can also reversibly nitrosylate cysteine residues and inhibit mitochondrial cytochrome c, leading to increased production of superoxide that locally reacts with NO to form peroxynitrite (the extremely reactive nucleophile ONOO-) (Cobb and Cole, 2015)
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