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The study identified demographic-specific signals warranting clinical vigilance

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Ha U, Herpich C, Norman K

Often referred to as the body's "master antioxidant," it helps protect cells from oxidative stress caused by free radicals

As pH-dependent dissociation of ligand-receptor complexes within acidic endosomes is known to influence post-endocytic receptor sorting (Borden et al., 1990), we wondered if the impact of low pH might specifically affect interactions made by the positively charged lixisenatide C-terminus, modulating intra-endosomal binding and thereby explaining its different recycling rate