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Methods Mice Small and large intestinal tissues used in the ex vivo organ culture system were dissected from sacrificed C57BL/6J (B6) mice

Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

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Analgesic activity in chronic pain models appears in the older literature, as do neuroprotective effects, effects on oxidative stress and on inflammation, and general neuromodulatory or neuromodulation framing

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