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In this manner, oxidized glutathione actually depletes antioxidants
Other proposed mechanisms that could account for the cardiorenal benefits of SGLT2 inhibitors include (Zelniker and Braunwald, 2020): Reduced visceral adiposity resulting in a fall in adipose tissue-mediated cytokine production and a decreased inflammatory effect reducing atherosclerosis, and benefiting HF and renal function
Evidence Sodium-glucose cotransporter 2 inhibitor (SGLT2i) Mechanism of action SGLT2i drugs act by blocking the sodium-glucose cotransporter in the proximal tubule of the nephron, leading to glucosuria and natriuria
Science 350 , 13911396 (2015)
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