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It has been observed that the active-site Ca 2+ coordinates with four acidic residues and if any of the residues are mutated then a greater Ca 2+ concentration is needed for catalysis

Niklewicz A et al

IGlarLixi is a fixed-ratio combination of insulin glargine and lixisenatide, containing 100 U/mL of glargine and 33 lg/mL of lixisenatide in a 3-mL prefilled injection pen

Genome-wide identification of genes required for alternative peptidoglycan cross-linking in Escherichia coli revealed unexpected impacts of -lactams