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The most specific antibodies are directed at the amidated C-terminus of GLP-1
A randomised trial found that patients who adhered to a low-calorie diet while on liraglutide lost significantly more weight than those who did not modify their diet, averaging an additional 3 kg over six months
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Dosing frequency Once daily: 200-300 mcg, typically before bed Simplest protocol Aligns with natural nighttime GH surge Good for anti-aging and general wellness Twice daily (preferred for most goals): 100-150 mcg morning (fasted or post-workout) 100-150 mcg before bed Better mimics natural pulsatile release Superior for muscle growth and fat loss Three times daily (advanced): Used by some athletes and bodybuilders Morning, post-workout, and bedtime 100 mcg per dose Requires more commitment Timing considerations Best times to inject: Before bed: Aligns with natural GH peak during sleep
In addition, it can result in seizures in individuals with seizure disorders and muscle weakness in those with uremia [10]
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