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Zheng Y, Chen J, Craven M, Choi NW, Totorica S, Diaz-Santana A, Kermani P, Hempstead B, Fischbach-Teschl C, Lopez JA, Stroock AD (2012) In vitro microvessels for the study of angiogenesis and thrombosis

The development of active targeting systems (e.g., antibody or peptide-guided) may help address this issue but faces new challenges such as high cost and poor stability

DOI: 10.2174/1381612824666180712110447

Notably, it demonstrated slow metabolism within the brain and enhanced stability at physiological temperatures compared to rapamycin, another mTOR inhibitor (Cassano and Magini 2019)