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2) insulin resistance leading to decreased glucose uptake by peripheral tissues (muscle and adipose)

Many GLP-1 weight loss medications are considered for adults with obesity or adults with overweight and at least one weight-related health condition, such as high blood pressure, high cholesterol, type 2 diabetes risk, or similar metabolic concerns

J Clin Invest 2008

While Semaglutide decreases appetite and improves glucose metabolism, Ipamorelin supports the bodys ability to preserve lean mass and metabolize fat more efficiently