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Laboratories occasionally report it separately as active B12 or holotranscobalamin
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While the FDA label historically suggested short-term use of up to 12 weeks, clinical evidence supports longer-term use under physician supervision for appropriate patients
In very rare cases, they could have a severe allergic reaction called anaphylaxis
How Vitamin B12 Affects Brain Chemistry and Stress Systems Neurotransmitter production B12, together with folate and B6, is essential for the methylation reactions that produce serotonin, dopamine, norepinephrine, and GABA the neurotransmitters most directly involved in regulating mood, motivation, calm, and emotional stability
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