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For instance, post hoc analyses from SURMOUNT-1 through SURMOUNT-4 [73] and from across the SURPASS program [74] showed that weight reduction with tirzepatide was neither solely nor fully associated with reported gastrointestinal adverse events, challenging the traditional assumption that nausea and vomiting are significant mediators of weight reduction

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Recent data demonstrate that acute central administration of 5 g of the centrally selective TGR5 agonist, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide, significantly reduces body weight gain in mice

However, the recent inclusion of prescription drugs in their programme has raised questions about the validity of this approach

Postpartum dietary, sleep, and physical activity behaviors: A qualitative study to inform efforts to address postpartum weight retention