Diabetes Obesity Metab 22:335345 Awad A, Madla CM, Mccoubrey LE, Ferraro F, Gavins FK, Buanz A, Gaisford S, Orlu M, Siepmann F, Siepmann J (2022) Clinical translation of advanced colonic drug delivery technologies
In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]
10.1038/nchem.1076 Nat
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These involve oral capsules, injectable administration, localized subcutaneous injections, systemic strategies, and combination stacking