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R., & Imrie, A

In research settings, it is studied for its apparent role in tissue repair, angiogenesis, nitric oxide system interactions, and musculoskeletal healing mechanisms in vitro and animal model studies

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Specifically, increased expression of peroxisome proliferator-activated receptor- coactivator-1 protein, a key regulator of mitochondrial biosynthesis, disrupts the mitochondrial structure and leads to dysfunctional proliferation, which is involved in the development of certain cardiac diseases, such as heart failure and atherosclerosis (45)

mitochondrial, SHMT2) catalyzes the transfer of the beta carbon of serine to tetrahydrofolate (THF) to form glycine and one-carbon units, 5,10-methylene-THF (Figure 1), which is critical for nucleotide synthesis