Lancet 397 (10286), 17361748
B12 injections effectively treat deficiency symptoms including chronic fatigue, mental fog, memory problems, numbness or tingling in extremities, pale skin, general weakness, and irritability in affected patients.
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In the 26-week study, PG-102 was administered at 2, 5, or 10 mg/kg once weekly for 26 consecutive weeks
It is a plausible mechanism via which GLP-1 may lead to intake suppression since activation of GLP-1 via EX4 injection was shown to decrease the motivation to obtain food (Dickson et al., ad libitum fed rats indicating that this response is robust (Dickson et al., ad libitum condition in which some rats still choose to expend a significant amount of work for their sugar reward (high-responders)