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Chronic stress signals, including hyperglycaemia, inflammation, neurohormonal activation, and mechanical overload, promote the activation of cardiac fibroblasts and the accumulation of extracellular matrix within the myocardium

In addition, cell autonomous primary astrocytopathies can give rise to aberrant astrocytes which drive neuropathological progression, and there is now mounting interest in how astrocytes that are reactive or diseased might have detrimental effects on the outcome of disorders

Some studies have explored sexual function in patients using GLP-1 receptor agonists more broadly

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