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For both injection and tablet formulations, a gradual doseescalation schedule over approximately 16 weeks (injection) or 90 days (tablets) is standard to improve GI tolerability. For prescribers , key considerations include: Confirming that the intended use is FDAapproved (CV risk reduction, chronic weight management, or adult MASH with F2F3 fibrosis) and that BMI and comorbidity criteria are met. Excluding contraindications (MTC/MEN 2, prior anaphylaxis/angioedema to semaglutide) and identifying risk factors such as prior pancreatitis, gallbladder disease, severe GI motility disorders, and advanced diabetic retinopathy

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Simple timing framework Baseline Discuss baseline labs before starting, especially with diabetes, thyroid cancer history, gallbladder history, pancreatitis history, sleep apnea, edema, cancer history, or kidney disease

Proper handling helps preserve peptide integrity throughout the duration of research