Lately, health authorities have approved certain formulations of GLP-1 medicines, making them safe choices for people struggling with weight issues
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Preclinical studies demonstrated that GLP-1 receptor agonists increased bone formation and reduced bone resorption in metabolic bone disease models, including diabetic osteoporosis, postmenopausal osteoporosis, and glucocorticoid-induced osteoporosis
We examine here how these models have been improved with attention to physiological dimensions, geometry, and proximity to different cell types and simulation of blood flow past exposed endothelial cells (Figure 2)