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Improved Skin Texture: Smoother and more refined skin
873 The expression of ACSL4 and 4-HNE increase in the cartilage of OA patients and OA mice, while metformin increases p-AMPK and p-ACC levels in IL-1-treated chondrocytes, reverses ACSL4 and 4-HNE positive chondrocytes and OA lesions, and improves the ferroptosis sensitivity of chondrocytes through the AMPK/ACC pathway
Tested animals experienced higher weight gain and increased weight of some of their organs (organomegaly)
Given the banal nature of this ingredient, supplementation is sensible & may contribute at best to the placebo effect
Studies published in English were included to ensure accuracy in data interpretation and synthesis, as well as to maintain consistency in the analysis
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