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The similar viewpoints were also supported by other critical reviews and clinical trials (5558), and inferred that GLP-1RA could be considered in patients at a high risk of, or with established cardiovascular diseases to improve the prognosis of cardiovascular events (especially nonfatal stroke), whilst SGLT2i could be recommended for patients with heart failure or chronic kidney diseases

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Potential Risks and Side Effects of Combining These Strategies Stacking GLP-1 medications with strict intermittent fasting increases the risk of nausea, vomiting, and dehydrationparticularly during dose escalation weeks

Gene Expression GPCR signaling regulates gene expression by activating intracellular pathways that influence transcription

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