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The group used cell-type-specific disruption of TrkB signalling in the indirect pathway spiny projection neurons (iSPNs), the cells most affected by HD in the early phase
Gastroenterology 2024;167(2):402404.e3
Inositol is best understood as a structural building block and a signaling helper: It helps form cell membranes It helps cells communicate internally Cells use inositol-containing compounds (including inositol phosphates signaling molecules derived from cell membranes) as part of major signaling networks that influence many processes across the body
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