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Worryingly however, 26.8% of patients had to discontinue the trial due to the severity of side-effects, although it must be noted that this was in part due to the lack of a run-in (A time frame where drug dosage is started from a low dosage and then escalated over time until the highest tolerable dose for the patient is reached) [40]

Access limitations or urgent medical need for metabolic control In some real-world cases, patients may face barriers to thyroid care (such as long wait times for endocrinology appointments) but have immediate access to a weight loss or diabetes program that includes GLP-1 medications

Dose escalation is occasionally used in longer protocols (8+ weeks) where initial high-dose loading aims to saturate tissue receptors, followed by lower maintenance doses to sustain gene expression changes

These metabolic shifts were significantly related to changes in body weight, abdominal fat, and measures of insulin sensitivity and lipid metabolism

These dietary approaches involve less frequent feedings and larger meals, which can provide similar decreases in hunger