The central role of the gut-liver axis is demonstrated by the reproducibility of these effects through fecal microbiota transplantation and their reversal upon FXR activation (9)
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The attractiveness of targeting fungal sulfur metabolism is further enhanced considering emerging links between hitherto cryptic and often apparently distinct biosynthetic pathways, such as those involving SAM/SAH homeostasis, gliotoxin, related ETPs and EGT
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