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The glucagon receptor effects may produce sensations you did not experience on tirzepatide, including mild thermogenic warmth and occasional changes in skin sensitivity

Genetic variants including GIPR rs1800437, FTO rs9939609, and MC4R rs17782313 relate to the biological pathways these medications act on

Plasma ghrelin levels in humans rise 12 h before the onset of a meal and fall to trough levels 30 min after the end of the meal 18,19

Understanding these expected changes helps distinguish normal responses from concerning developments requiring medical attention

Your clinician needs the real picture to adjust the plan