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Novo Nordisks highly anticipated phase 3 EVOKE and EVOKE+ trials evaluated oral semaglutide (Rybelsus), a GLP-1 receptor agonist, in 3,808 individuals with early-stage Alzheimers disease, aiming to slow cognitive decline over a 2-year period
46 In patients with T2DM, the Tirzepatide versus Semaglutide once weekly in patients with T2DM (SURPASS-2) trial compared tirzepatide with semaglutide 1 mg (both as add-on therapies to metformin) and found tirzepatide was either noninferior or superior at all doses (5 mg, 10 mg 15 mg), for both HbA 1c reduction and weight loss at 40 weeks
Intended strictly for research use only and not for human consumption
The exendin-4 treatment has been shown to reduce cocaine self-administration, suggesting that the GLP-1 system may be a novel target of drug addiction (Sorensen et al., 2015)
in financing Hanmi starts phase 3 diabetes trial for GLP-1 drug ahead of obesity launch Kim Ji-hye [email protected]
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