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MOTS-C is on the WADA prohibited list as a peptide hormone

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10.1016/j.ejphar.2007.05.072 69 TodaN.NakanishitodaM

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Histone Deacetylase Inhibitors MS-275 and SAHA Induced Growth Arrest and Suppressed Lipopolysaccharide-Stimulated NF-kappaB P65 Nuclear Accumulation in Human Rheumatoid Arthritis Synovial Fibroblastic E11 Cells

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They are also slow to act and have significant chronic side effects

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These methods require more skill but offer greater experimental flexibility

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