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doi: 10.1007/s40259-013-0057-y 127 McCartyDColemanMBolandCL
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In the COMBINE 3 trial in individuals with T2D inadequately controlled on daily basal insulin, IcoSema provided non-inferior reduction in HbA 1c from baseline to week 52 and superior body weight change and rate of combined clinically significant or severe hypoglycemia compared with basal-bolus insulin treatment that included once-daily insulin glargine U100 and insulin aspart given two to four times per day with main meals [15]
Most users see initial appetite suppression within 1-2 weeks, but meaningful weight loss typically emerges over 8-12 weeks at a stable therapeutic dose
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