More estrogen means more natural GLP-1 production
When the body loses weight on these medications, it loses both fat and lean muscle mass
Mol Neurobiol 55(4):30073020 Liu Y, Wang L, Pan D, Li M, Li Y, Wang Y, Xu Y, Wang X, Yan J, Wu Q, Lu L, Yuan K, Yang M (2021) PET evaluation of light-induced modulation of microglial activation and GLP-1R expression in depressive rats
Variants in genes such as GIPR (rs1800437), and FTO (rs9939609) affect how efficiently your cells bind and respond to these medications, potentially determining whether you'll need higher or lower doses
Periodic maintenance injections may also be necessary to support ongoing weight loss and overall health.