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Their weight remained relatively stable, which may reflect engagement in alternative weight-loss efforts post-discontinuation

It is particularly important because it supports the view that GLP-1RA treatment should be understood as a systemic metabolic intervention rather than a weight-loss effect alone

In 2025, semaglutide received approval from the U.S

However, the authors of this study noted that there were no clinically significant differences, and both drugs were effective for their intended uses

They should be considered superior in most patients, including those with HF and CKD.3 However, ischaemia prevention is superior for GLP-1 RAs, thus making them preferable in patients with predominant ASCVD risk.3 Differences in routes of administration and adverse effect profiles may also play a role in prescription decisions