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Additionally, while some studies raise concerns about GLP-1s increasing depression, anxiety, and suicidal thoughts, other studies point in the opposite direction, noting a decrease in depressive symptoms, improved cognitive function, and an increase in feelings of self-mastery

If you are starting at 0.25 mg, precision matters most

doi: 10.1016/j.cmet.2017.10.009 112 CannonBNedergaardJ

10.1186/s40168-021-01126-6 Summary Keywords butyrate, diabetes, GLP-1, gut microbiota, leonurine, MPC2 Citation Zhang Y, Chen W, Yu X, Feng J, Sammad A, Wang Z and Yin K (2026) Leonurine ameliorates experimental type 2 diabetes through gut microbiota remodeling, enhanced butyrate production, and MPC2 activation to restore GLP-1 secretion

Months 1 to 2: Improved sleep quality, faster recovery, subtle shifts in energy