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Metabolism of OPZ results in the production of a minor oxo analog (2), and the major dimethylated pyrrolopyrazine (3) through the biological methylation of the intermediate pyrrolopyrazine thione (4)
326 In macrophage, high levels of CD38 induced by LXR agonists reduce NAD + levels and interfere with cytoskeletal rearrangements triggered by invasive bacteria, protecting host macrophages from substantial infection
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For instance, DAAs express high levels of GFAP, a common marker of astrocyte activation (Liddelow et al., 2017)
