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The activation of GLP-1R by a specific agonist induces an increase in intracellular cAMP levels, which leads to channel opening

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24 Therefore, considering that GLP-1R is widely distributed in the body, that COPD and diabetes interact with each other and share common pathogenic mechanisms, and that GLP-1 and its receptor agonists have been widely used in diabetic patients and have demonstrated hypoglycemic, pro-inflammatory and anti-inflammatory factors, oxidative stress, neurogenesis and vascular protection, 33 then GLP-1 and its receptor agonists also have a role to play in COPD patients

Cilette believes that Ozempic is the culprit

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