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Gene-level modulation: Pickart & Margolina 2018 documented activity across ~4,000 human genes, with fibroblast expression patterns shifting closer to younger cells
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We do not know whether the insulin-sensitizing effects of GLP-1/GIP agonism adequately counterbalance the insulin-desensitizing effects of GH elevation when both occur simultaneously
This morphological variability likely affects mitochondrial functions, such as ATP production and Ca 2+ buffering
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