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It activates several overlapping pathways, notably VEGFR2 and nitric oxide synthesis via the Akt-eNOS axis, promoting angiogenesis, fibroblast activity, and neuromuscular stabilization
They also tune kinase pathways (e.g., MAPK/PI3K-Akt/AMPK) that govern survival and metabolism, and many exhibit context-dependent estrogenic/anti-estrogenic signaling
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