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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

That is roughly double to triple the discontinuation rate seen with semaglutide

[13] There have also been rare reports of high-dose vitamin B (as in injectable form) precipitating skin outbreaks such as acne or rosacea in susceptible persons

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