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Research suggests that cycling protocols (3-6 months on, 1-2 months off) provide the best balance of effectiveness and long-term safety for extended research uses

Elevated OS has been associated with systemic manifestations, including heightened lipid peroxidation, which correlates with mood disturbances, sleep disorders, and other health concerns (152)

Preventing glucose absorption with phloridizin abolishes glucose-stimulated GIP secretion in healthy wild-type (Sykes et al., 1980) and Kir6.2 / mice (Ogata et al., 2014), even in the presence of a -methyl-D-glucopyranoside (Moriya et al., 2009)

Malaguarnera, Michele (June 2013)

however, in inflammatory disease states, particularly when intestinal barrier integrity and function may be compromised, LPS can enter the circulation, where it can activate TLR4 on inflammatory cells and trigger a systemic inflammatory response