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Factors that Contribute to Knee OA Knee OA typically develops after age 50, although it can begin earlier, and women are up to twice as likely to develop the condition

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Across all targets, future studies should emphasise quantitative sequence-structure-selectivity relationships, including how donor sets, geometry constraints, and microenvironment tuning govern discrimination between closely related ions and oxidation states, with the rapid progress in elucidating REE-protein binding over the last decade providing a useful template for this approach