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Beyond-use dating principles from the United States Pharmacopeia General Chapter treat preservative-containing solutions as having longer safe in-use windows than preservative-free ones

Avoid repeated temperature cycling, and never freeze a reconstituted vial, which can precipitate the peptides out of solution

(2021) "Once-weekly semaglutide in adults with overweight or obesity" New England Journal of Medicine, 384(11) 2

While this does not directly relate to peptide quality, it raises questions about quality control across the product line

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