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Metformin ameliorates lipopolysaccharide-induced depressive-like behaviors and abnormal glutamatergic transmission
The addition of GIP agonism is what separated tirzepatide from pure GLP-1 drugs, and researchers tracking the progression from semaglutide to tirzepatide to retatrutide can see how each additional receptor adds another layer of metabolic benefit
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The honest reader holds both facts at once: a real signal, measured in a way that tends to overstate signals
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