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Induction of HO-1 reduced inflammatory cytokines, such as TNF- and IL-6, increased antioxidants, and improved angiogenesis in wound tissues of diabetic rats, thereby wound healing was accelerated in the diabetic state [118]

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Its exceptional structural stability, retained activity in gastric juice for over 24 hours, tolerance across pH 1-11, derives from its high proline content and absence of cleavage-prone motifs in the 15-residue sequence

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