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They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding ~300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects
The 2.5 mg dose is better called the low-dose starter, because it is the labeled start and now has short direct non-diabetic data behind it. Microdosing has been used for tolerability testing, metabolic-marker support, step-down protocols, and maintenance, not for proven long-term obesity outcomes
Thus, the study benefits from the fact that the necessary translations, adaptations, piloting and psychometric evaluations have been completed for the study setting
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Intramuscular (IM) Injections: Intramuscular injections deliver B12 directly into muscle tissue, typically in the vastus lateralis (outer thigh) or deltoid (upper arm)
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