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Studies in germ-free mice show they have an exaggerated HPA stress response, which can be normalized by colonization, indicating the microbiota is essential for HPA calibration (Evrensel and Ceylan, 2015
Liver dysfunction does not explain every mood or cognitive symptom, but oxidative stress, altered medication metabolism, gut-derived inflammation, ammonia, copper imbalance, low glutathione and impaired methylation may reduce neurological resilience in selected patients
Antioxidant stress BPC 157 can activate antioxidant enzymes (such as SOD) and reduce oxidative stress damage
doi:10.1007/s11356-021-17484-5
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