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Specifically, Semaglutide (SEMA), a glucagon-like peptide-1 receptor agonist (GLP-1 RA) molecule approved for the treatment of both type 2 diabetes (T2D) and obesity associated with significant improvement in metabolic syndrome parameters [43, 44], was tested since fasting HFD mice showed lower GLP-1 circulating levels (Suppl
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The molecule is permeable to cell membranes (confirmed by Caco-2 assay) and highly selective, without inhibitory effect on other SAM-dependent methyltransferases
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