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JAMA, 324 (21), 2186-2197
Why Biologic Microheterogeneity Makes Identity Scientifically Impossible Biologics are manufactured inside living cells
It may be that short-acting GLP-1RAs act more like endogenous GLP-1 and communicate to the brain primarily via the vagus nerve, whereas long-acting GLP-1RAs like liraglutide and semaglutide primarily access the brain directly
And now we have evidence that a dual agonist is better than a single agonist. The study compares real-world liver and cardiovascular outcomes for the two drugs in MASLD patients with obesity, and type 2 diabetes
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