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In contrast to PD-L1-mediated T-cell dysfunction induced by glutamine limitation, DON and its prodrug JHU-083 skew CD8(+) T cells toward a highly activated, persistent, and proliferative phenotype, thereby facilitating immunogenic cancer cell death 58,149,150 (Fig
Febrile reactions, infections, thrombosis, phlebitis, extravasation
Histamine Overload and MCAS Flares: As a key component of Phase II liver detoxification, glutathione accelerates the clearance of circulating histamine and inflammatory cytokines, helping to reduce flushing, itching, and sudden allergic-like reactions
doi: 10.1023/A:1010635131228 185 LiXZhangDVatnerDFGoedekeLHirabaraSMZhangYet al