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& Zaher, S

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Prednisolone was associated with a non-significant decrease in 28-day mortality, with no change in mortality at 90 days or 1 year in a well-conducted study [26]

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Conversely, in a recent randomized, double-blind, placebo-controlled study involving twenty healthy volunteers, a once-weekly injection of a GLP-1R agonist, dulaglutide, for three weeks did not influence HPA axis activity, showing no significant effects on circadian rhythms of blood or salivary cortisol secretion, and the level of this hormone also was not changed after the dexamethasone suppression test in comparison with the placebo-receiving group [78]

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