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Reason #1: Early-Phase Injury Priorities Are Often Different Acute and subacute injury phases emphasize: Inflammatory modulation Vascular response Cellular migration Protection from excessive load In many musculoskeletal cases, practitioners prioritize peptides or strategies that influence early inflammatory cascades and cellular signaling before emphasizing collagen remodeling agents

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Goto H, Nomiyama T, Mita T, Yasunari E, Azuma K, Komiya K, et al

Occasional puffiness from sodium or activity fluctuation is normal physiology, not a sign the medication is failing or causing harm