Why Individual Responses to GLP-1 Vary: Genetic and Biomarker Context Not all patients experience sulfur burps or gastrointestinal side effects at the same intensity
GraphPad Prism 6.0 software (La Jolla, CA, USA) was used for statistical analyses
Patients may feel the medication works less dramatically over time because they have adapted to its effects

Patients should contact their GP or diabetes specialist nurse if they experience: Severe or persistent vomiting that prevents adequate fluid or food intake, as this increases the risk of dehydration and hypoglycaemia Severe abdominal pain , particularly if constant or radiating to the back, which could indicate pancreatitisa rare but serious adverse effect of GLP-1 receptor agonists Sudden pain in the right upper abdomen, fever or jaundice , which may indicate gallbladder problems (cholelithiasis or cholecystitis) Blood in stools or black, tarry stools Unexplained weight loss beyond what is expected from the medication's therapeutic effect Signs of dehydration , including reduced urine output, dizziness, or confusion Persistent diarrhoea lasting more than a few days Symptoms that significantly impair quality of life or prevent adherence to the medication regimen Pancreatitis is a particular concern with semaglutide, though it remains uncommon

Heart rate elevating faster during cardio means lower work capacity at any given perceived effort level