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In a study of healthy men, Amarasates mode of action was confirmed as being a potent stimulant of endogenous production of gut hormones, including GLP-1, CCK, and PYY.1 Taken an hour before a meal, this nutraceutical increased basal levels of GLP-1 and CCK to six times above baseline, and to twice the typical release occurring after eating (Figure 1).1 Moreover, Amarasate enhanced the release of GLP-1 and other hormones in the same physiological pattern seen normally

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Levels of HNMT activity in humans are regulated genetically