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For instance, semaglutide, a novel GLP-1RA, has demonstrated promise in ameliorating EAE-induced cognitive and physical dysfunction in mice

however, GLP-1 receptor agonists and SGLT2 inhibitors are more strongly recommended over DPP-4 inhibitors

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The mechanism mediating the ability of PYY to regulate food intake is contentious but likely involves alterations in gastric emptying, vagal neuronal signaling to the hypothalamus 200,203,204 , and direct endocrine activation of the ARC 200

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