2025 saw a bidding war between Pfizer and Novo Nordisk for Metsera and its portfolio of obesity agents, which was ultimately won by Pfizer for up to $10 billion
On one hand, FGF21 appears to increase peripheral anabolic signaling, for example through muscle and adipose tissue insulin sensitization, under conditions of adequate or excessive energy intake, as described in detail below
Some studies find that supplements of carnitine taken prior to training may improve performance in high-intensity and endurance sports
Personalized Dosing Some patients may begin treatment with a gradual titration schedule to support comfort, while others may be eligible for faster escalation
This effect seems to be dose-related, as patients receiving 5 mg daily showed a mean reduction of about 100 cells/mcL, and those receiving 2.5 mg daily did not have a decrease in lymphocyte count